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Translocation: Types, Causes, and Related Conditions - Verywell …
https://www.verywellhealth.com/translocation-7486081
WEBJun 28, 2023 · Translocation is a genetic abnormality in which chromosomes break and relocate to another chromosome. This can cause serious health and genetic conditions like Down syndrome and cancer. Translocation can be caused by radiation and chemotherapy, oryy they can happen spontaneously.
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What Are Translocations? What Disorders Do They Cause? - WebMD
https://www.webmd.com/children/what-are-translocations
WEBJul 21, 2022 · What Is a Translocation Mutation? A change in chromosome structure and content caused by translocation is a translocation mutation. Many genes may be transferred between...
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Chromosomal translocation - Wikipedia
https://en.m.wikipedia.org/wiki/Chromosomal_translocation
WEBIn genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal , and Robertsonian translocation.
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Translocation - National Human Genome Research Institute
https://www.genome.gov/genetics-glossary/Translocation
WEBApr 19, 2024 · A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of chromosomal translocations can be important for the diagnosis of certain genetic diseases and disorders.
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The biogenesis of chromosome translocations - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337718/
WEBTranslocations play an undisputed role in the initial steps of carcinogenesis and it is estimated that they are causal in ~20% of cancers 2. Beyond their role as disease agents, translocations are used as decisive diagnostic indicators, as they are easily and accurately detected using cytogenetic methods.
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Human Chromosome Translocations and Cancer - Nature
https://www.nature.com/scitable/topicpage/human-chromosome-translocations-and-cancer-23487/
WEBIn a translocation, a segment from one chromosome is transferred to a nonhomologous chromosome or to a new site on the same chromosome. Translocations place genes in new linkage relationships and...
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Mechanisms driving chromosomal translocations: lost in time
https://www.nature.com/articles/s41388-021-01856-9
WEBJun 8, 2021 · Translocations are simple “cut and paste” structural genome variants (SVs) that can arise when there are two co-existing breaks on different chromosomes, and the incorrect ends are joined...
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Chromosome Abnormalities Fact Sheet - National Human …
https://www.genome.gov/about-genomics/fact-sheets/Chromosome-Abnormalities-Fact-Sheet
WEBAug 15, 2020 · Translocations: A portion of one chromosome is transferred to another chromosome. There are two main types of translocation. In a reciprocal translocation, segments from two different chromosomes have been exchanged.
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Mechanisms driving chromosomal translocations: lost in time and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238880/
WEBAbstract. Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it is important to understand the mechanisms leading these chromosome rearrangements.
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The biogenesis of chromosome translocations | Nature Cell Biology
https://www.nature.com/articles/ncb2941
WEBApr 1, 2014 · The biogenesis of chromosome translocations. Vassilis Roukos & Tom Misteli. Nature Cell Biology 16 , 293–300 ( 2014) Cite this article. 10k Accesses. 109 Citations. 16 Altmetric. Metrics....
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