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RNA-dependent RNA polymerase - Wikipedia
https://en.wikipedia.org/wiki/RNA-dependent_RNA_polymerase
WEBRNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template.
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Coronaviruses: An Updated Overview of Their Replication and
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682345/
WEBThe replicase gene constitutes two ORFs, rep 1a and rep 1b, which are expressed by a ribosomal frameshifting mechanism. The expanded regions below show the structural and accessory proteins in the 3′ regions of α-CoVs (HCoV-229E), β-CoVs (MHV, SARS-CoV, and MERS-CoV), γ-CoVs (IBV) and δ-CoVs (PDCoV).
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Replicase Definition & Meaning - Merriam-Webster
https://www.merriam-webster.com/dictionary/replicase
WEBJul 6, 2022 · The meaning of REPLICASE is a polymerase of viruses that promotes synthesis of a particular RNA in the presence of a template of RNA.
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The coronavirus replicase - PubMed
https://pubmed.ncbi.nlm.nih.gov/15609509/
WEBAbstract. Coronavirus genome replication and transcription take place at cytoplasmic membranes and involve coordinated processes of both continuous and discontinuous RNA synthesis that are mediated by the viral replicase, a huge protein complex encoded by the 20-kb replicase gene.
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The Coronavirus Replicase - PMC - National Center for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121973/
WEBCoronavirus genome replication and transcription take place at cytoplasmic membranes and involve coordinated processes of both continuous and discontinuous RNA synthesis that are mediated by the viral replicase, a huge protein complex encoded by the 20-kb replicase gene. The replicase complex is believed to be comprised of up to 16 viral ...
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Introduction to RNA Viruses - PMC - National Center for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173417/
WEBSep 1, 2017 · RdRps of RNA viruses probably arose from a common ancestor. The RdRp, in association with other proteins required for viral genome synthesis is often called the replicase complex. The replicase complex consists of the set of proteins required to produce infectious genomes.
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Structures and functions of coronavirus replication–transcription
https://www.nature.com/articles/s41580-021-00432-z
WEBNov 25, 2021 · The viral genes fall into three groups (Fig. 2a): replicase ORF1a and ORF1b, which are translated from gRNA with ORF1b expression depending on −1 PRF; ORFs encoding the four ‘universal ...
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Structural basis for substrate selection by the SARS-CoV-2 replicase
https://www.nature.com/articles/s41586-022-05664-3
WEBFeb 1, 2023 · Structural basis for substrate selection by the SARS-CoV-2 replicase | Nature. Article. Published: 01 February 2023. Structural basis for substrate selection by the SARS-CoV-2 replicase....
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The Coronavirus Replicase | SpringerLink
https://link.springer.com/chapter/10.1007/3-540-26765-4_3
WEBOct 25, 2005 · Coronavirus genome replication and transcription take place at cytoplasmic membranes and involve coordinated processes of both continuous and discontinuous RNA synthesis that are mediated by the viral replicase, a huge protein complex encoded by the 20-kb replicase gene.
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Amplifying RNA Vaccine Development | New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMcibr2009737
WEBJun 17, 2020 · The replicase machinery is therefore provided “in trans” (i.e., two genes acting together but on different RNAs) by a self-amplifying RNA or a nonreplicating mRNA and mediates replication of the...
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