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Luspatercept - Wikipedia
https://en.m.wikipedia.org/wiki/Luspatercept
WebLuspatercept, sold under the brand name Reblozyl, is a medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.
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Luspatercept Uses, Side Effects & Warnings - Drugs.com
https://www.drugs.com/mtm/luspatercept.html
WebDec 6, 2023 · Luspatercept is used to treat anemia (lack of red blood cells) in adults with beta thalassemia who need to have regular red blood cell transfusions. Luspatercept may also be used for purposes not listed in this medication guide. Luspatercept side effects.
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Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
https://www.nejm.org/doi/full/10.1056/NEJMoa1908892
WebJan 8, 2020 · Luspatercept is a recombinant fusion protein that binds select transforming growth factor β superfamily ligands to decrease SMAD2 and SMAD3 signaling, thereby enabling erythroid maturation by...
DA: 96 PA: 61 MOZ Rank: 19
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Luspatercept - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK560635/
WebJul 10, 2023 · Luspatercept is a medication used to manage and treat anemia in myelodysplastic syndromes, primary myelofibrosis, and beta-thalassemia. It is a recombinant fusion protein that binds transforming growth factor-beta ligands to reduce SMAD2 and SMAD3 signaling.
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Luspatercept: Uses, Interactions, Mechanism of Action
https://go.drugbank.com/drugs/DB12281
WebOct 20, 2016 · Luspatercept is an erythroid maturation agent used to treat anemia secondary to beta thalassemia, myelodysplastic syndromes, and neoplasms. Brand Names. Reblozyl. Generic Name. Luspatercept. DrugBank Accession Number. …
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FDA approves luspatercept-aamt for anemia in adults with MDS
https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-luspatercept-aamt-anemia-adults-mds
WebOn April 3, 2020, the Food and Drug Administration approved luspatercept-aamt (REBLOZYL, Celgene Corporation) for the treatment of anemia failing an erythropoiesis stimulating agent and...
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The use of luspatercept for thalassemia in adults
https://ashpublications.org/bloodadvances/article/5/1/326/474891/The-use-of-luspatercept-for-thalassemia-in-adults
WebJan 12, 2021 · Luspatercept is an activin receptor ligand trap that has been shown to enhance late-stage erythropoiesis in animal models of β-thalassemia. A multicenter, international, phase 2 dose-finding study was initiated in adult patients with β-thalassemia, either non–transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT).
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A Phase 3 Trial of Luspatercept in Patients with Transfusion …
https://www.nejm.org/doi/full/10.1056/NEJMoa1910182
WebMar 25, 2020 · Luspatercept is a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands and enhances late-stage erythropoiesis.
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Luspatercept-aamt - NCI - National Cancer Institute
https://www.cancer.gov/about-cancer/treatment/drugs/luspatercept-aamt
WebLuspatercept-aamt is approved to treat: Anemia caused by certain types of myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms. It is used in adults who need regular red blood cell transfusions and whose anemia did not respond to or cannot be treated with an erythropoiesis-stimulating agent.
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Reblozyl (luspatercept) dosing, indications, interactions, adverse
https://reference.medscape.com/drug/reblozyl-luspatercept-1000359
WebReblozyl (luspatercept) dosing, indications, interactions, adverse effects, and more. Limitation of use. Not for use as substitute for RBC transfusions in patients requiring immediate...
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