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ZRSR2 - My Cancer Genome
https://www.mycancergenome.org/content/gene/zrsr2/
webThe most common alterations in ZRSR2 are ZRSR2 Mutation (0.65%), ZRSR2 Loss (0.39%), ZRSR2 Nonsense (0.10%), ZRSR2 Amplification (0.09%), and ZRSR2 X276_splice (0.03%) . ZRSR2 GENIE Cases - Top Alterations
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ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and …
https://ashpublications.org/blood/article/136/Supplement%201/10/470256/ZRSR2-Mutation-Induced-Minor-Intron-Retention
webNov 5, 2020 · Here we uncover a heretofore unrecognized role of minor intron excision in regulating HSC self-renewal, a molecular link between ZRSR2 mutations and aberrant LZTR1 splicing and expression, and frequent LZTR1 minor intron retention in diverse cancers and cancer predisposition syndromes.
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Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic
https://www.nature.com/articles/s41375-022-01674-2
webAug 27, 2022 · Importantly, mutations in the splicing factor ZRSR2 frequently associate with alterations in the epigenetic regulator TET2. However, the impact of these concurrent mutations in hematopoiesis...
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ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS
https://ashpublications.org/blood/article/124/21/4609/94026/ZRSR2-Mutations-Cause-Dysregulated-RNA-Splicing-in
webDec 6, 2014 · Ours is a first study which demonstrates the functional consequences of ZRSR2 mutations in MDS and identifies a specific role of ZRSR2 in regulating RNA splicing. It underlines aberrant splicing of U12-type introns as a …
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Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair …
https://pubmed.ncbi.nlm.nih.gov/34615655/
webWe connect X chromosome mutations in ZRSR2 to an extremely male-predominant leukemia. Aberrant RNA splicing induced by ZRSR2 mutation impairs dendritic cell inflammatory signaling, interferon production, and apoptosis, revealing a sex- and lineage-related tumor suppressor pathway.
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Minor intron retention drives clonal hematopoietic disorders and
https://www.nature.com/articles/s41588-021-00828-9
webApr 12, 2021 · These data uncover minor intron recognition as a regulator of hematopoiesis, noncoding mutations within minor introns as potential cancer drivers and links among ZRSR2 mutations, LZTR1...
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Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2
https://ashpublications.org/blood/article/119/15/3578/105563/Frequency-and-prognostic-impact-of-mutations-in
webApr 12, 2012 · SRSF2 mutations may become useful for clinical risk stratification and treatment decisions in the future. Topics: mutation, myelodysplastic syndrome, srsf2 gene, sf3b1 gene, genes, protein p53, rna splicing. Introduction.
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ZRSR2 | Cancer Genetics Web - CancerIndex
http://www.cancerindex.org/geneweb/ZRSR2.htm
webGene Summary. ZRSR2. COSMIC, Sanger Institute. Somatic mutation information and related details. ZRSR2. GEO Profiles, NCBI. Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. Latest Publications: ZRSR2 (cancer-related) Ng IK, Ng C, Low JJ, et al.
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RNA splicing dysregulation and the hallmarks of cancer
https://www.nature.com/articles/s41568-022-00541-7
webJan 10, 2023 · ZRSR2, an X-linked gene, is mutated in 1–11% of MDS without ring sideroblasts, in 0.8–8% of CMML and at lower rates among other haematological cancers (Fig. 2a), with most mutations occurring...
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Zrsr2 Is Essential for the Embryonic Development and Splicing of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501576/
webSep 14, 2022 · ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2) is an essential splicing factor involved in 3′ splice-site recognition as a component of both the major and minor spliceosomes that mediate the splicing of U2-type (major) and U12-type (minor) introns, respectively.
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