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TFRC Gene - GeneCards | TFR1 Protein | TFR1 Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TFRC
WEBJan 3, 2024 · TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include Immunodeficiency 46 and Combined Immunodeficiency.Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle.Gene Ontology (GO) annotations related to this gene include RNA binding and double-stranded RNA binding.An important paralog of this gene is TFR2.
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Transferrin receptor 1 - Wikipedia
https://en.m.wikipedia.org/wiki/Transferrin_receptor_1
WEBTransferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] TfR1 is required for iron import from transferrin into cells by endocytosis. [7] [8]
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Role of TFRC as a Novel Prognostic Biomarker and in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965864/
WEBMar 16, 2022 · At present, a combination of multiple immunotherapies is often used to overcome the lack of immune response in cold tumors and transform cold tumors into hot tumors. In pancreatic cancer, TFRC is associated with the tumor immune cycle by analyzing the relationship between TFRC and the immune cycle.
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TFRC - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/immunology-and-microbiology/tfrc
WEBAR TFRC deficiency ( TFRC; OMIM # 616744) Definition: The TFRC gene encodes the transferrin receptor, which is important for cellular iron uptake. A missense mutation in TFRC, encoding transferrin receptor 1, causes this AR-CID. 169. Genetics: Homozygous missense mutations in the TFRC gene (Y20H) was …
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TFRC transferrin receptor [Homo sapiens (human)] - Gene - NCBI
https://www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Term=7037
WEBMar 17, 2024 · Summary. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] Expression.
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MYCN mediates TFRC-dependent ferroptosis and reveals
https://www.nature.com/articles/s41419-021-03790-w
WEBMay 19, 2021 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ...
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TFRC upregulation promotes ferroptosis in CVB3 infection via …
https://www.nature.com/articles/s41419-022-05027-w
WEBJul 11, 2022 · Cell viability. HeLa cells were seeded in 96‐well plates (5 × 10 3 cells/well). After 24 h, when the cells grew into a monolayer, they were infected with CVB3 and were harvested at different times.
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Transferrin Receptor-Mediated Iron Uptake Promotes Colon
https://pubmed.ncbi.nlm.nih.gov/36703617/
WEBTransferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, the mechanism whereby TFRC expression is maintained at high levels in iron-enriched cancer cells and the contribution of TFRC to cancer development are enigmatic.
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TFRC in cardiomyocytes promotes macrophage infiltration and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461419/
WEBAug 28, 2023 · 1. INTRODUCTION. Heart failure (HF), as a global pandemic with high incidence and prevalence, still seriously endangers human health. 1 Generally, the morbidity of HF is 1–20 cases per 1000 people in adult. 2 Besides, among HF patients, 51% of patients have severe HF. 3 Nowadays, several risk factors for HF have been identified, including smoking, arterial hypertension, diabetes mellitus ...
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Frontiers | Identification and validation of transferrin receptor
https://www.frontiersin.org/articles/10.3389/fnmol.2022.972308/full
WEBNov 22, 2022 · IntroductionTransferrin receptor protein 1 (TFRC), an ananda molecule associated with ferroptosis, has been identified as affecting a wide spectrum of pathological processes in various cancers, but the prognostic value correlates with the tumor microenvironment of TFRC in lower-grade glioma (LGG) is still unclear.Materials and methodsClinical pathological information and gene expression data ...
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