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Replication Fork | Science Primer
https://scienceprimer.com/replication-fork
webThe replication fork is a region where a cell's DNA double helix has been unwound and separated to create an area where DNA polymerases and the other enzymes involved can use each strand as a template to synthesize a new double helix. An enzyme called a helicase catalyzes strand separation.
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The Replication Fork: Understanding the Eukaryotic Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627427/
webJan 29, 2013 · The process of semiconservative replication suggested a geometry for the site of DNA replication, a fork-like DNA structure, where the DNA helix is open, or unwound, exposing unpaired DNA nucleotides for recognition and base pairing for the incorporation of free nucleotides into double-stranded DNA ( Figure 1 ).
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Replication Fork, Fork Protection Complex | Learn Science at …
https://www.nature.com/scitable/topicpage/replication-fork-stalling-and-the-fork-protection-14435782/
webFigure 1: Replication fork components. The RF is a multiprotein complex with helicase and DNA synthesis activities. It is called a fork because the structure resembles a two-pronged fork. The...
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9.2: DNA Replication - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Concepts_in_Biology_(OpenStax)/09%3A_Molecular_Biology/9.02%3A_DNA_Replication
webMar 17, 2022 · Figure \(\PageIndex{3}\): A replication fork is formed by the opening of the origin of replication, and helicase separates the DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase.
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Molecular mechanism of DNA replication - Khan Academy
https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/replication/a/molecular-mechanism-of-dna-replication
webThe double-stranded DNA of the circular bacteria chromosome is opened at the origin of replication, forming a replication bubble. Each end of the bubble is a replication fork, a Y-shaped junction where double-stranded DNA is separated into two single strands. New DNA complementary to each single strand is synthesized at each replication fork.
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DNA structure and replication review (article) | Khan Academy
https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/replication/a/hs-dna-structure-and-replication-review
webThe replication fork is the branched (forked) DNA at either end of the replication bubble. The replication complex is the group of proteins that help synthesize the new DNA strands. A replication unit is any chunk of DNA that is capable of being replicated — e.g. a plasmid with an origin of replication (ORI) is a replication unit.
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14.4: DNA Replication in Prokaryotes - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/General_Biology_1e_(OpenStax)/3%3A_Genetics/14%3A_DNA_Structure_and_Function/14.4%3A_DNA_Replication_in_Prokaryotes
webReplication in prokaryotes starts from a sequence found on the chromosome called the origin of replication—the point at which the DNA opens up. Helicase opens up the DNA double helix, resulting in the formation of the replication fork. Single-strand binding proteins bind to the single-stranded DNA near the replication fork to keep the fork open.
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Making Choices: DNA Replication Fork Recovery Mechanisms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098667/
webDNA replication forks are blocked by many obstacles including DNA lesions, inter-strand crosslinks, protein-DNA crosslinks, single strand breaks (SSB), DSB, ongoing RNA transcription, depletion of nucleotides, and overexpression of oncogenes ( …
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Eukaryotic DNA Replication Fork - PMC - National Center for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597965/
webJun 6, 2017 · 1. INTRODUCTION. Cellular DNA replication mechanisms are highly conserved. All organisms in the three kingdoms of life carry out semiconservative DNA replication, as originally hypothesized by Watson and Crick ( 1 ). All organisms also have solved the mode of replication of antiparallel double-stranded DNA (dsDNA) in a similar …
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14.3C: DNA Replication in Eukaryotes - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Book%3A_General_Biology_(Boundless)/14%3A_DNA_Structure_and_Function/14.03%3A_DNA_Replication/14.3C%3A_DNA_Replication_in_Eukaryotes
webOct 31, 2023 · As the DNA opens up, Y-shaped structures called replication forks are formed. Because two helicases bind, two replication forks are formed at the origin of replication; these are extended in both directions as replication proceeds creating a replication bubble.
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