Keyword Analysis & Research: pml rara

testing.com

https://www.testing.com/tests/pml-rara/

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nih.gov

https://pubmed.ncbi.nlm.nih.gov/31635329/

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139833/

WEBMar 8, 2020 · Although PML-RARA rearrangement is the cytogenetic hallmark of APL, in vitro studies performed on transgenic mice support the hypothesis that secondary … Author: Alessandro Liquori, Mariam Ibañez, Claudia Sargas, Miguel Ángel Sanz, Eva Barragán, José Cervera DOI: 10.3390/cancers12030624 Publish Year: 2020 Publication: Cancers (Basel). 2020 Mar; 12(3): 624.

Author: Alessandro Liquori, Mariam Ibañez, Claudia Sargas, Miguel Ángel Sanz, Eva Barragán, José Cervera

DOI: 10.3390/cancers12030624

Publish Year: 2020

Publication: Cancers (Basel). 2020 Mar; 12(3): 624.

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139833/figure/cancers-12-00624-f001/

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nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK459352/

WEBNov 9, 2019 · Acute promyelocytic leukemia is a distinguished subset of acute myeloid leukemia which is characterized by fusion gene … Author: Shashank R. Cingam, Nebu V. Koshy Published: 2023/06/26 Publish Year: 2021

Author: Shashank R. Cingam, Nebu V. Koshy

Published: 2023/06/26

Publish Year: 2021

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nih.gov

https://pubmed.ncbi.nlm.nih.gov/31635329/

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pathologyoutlines.com

https://www.pathologyoutlines.com/topic/molecularPMLRARA.html

WEBJun 7, 2022 · Retinoic acid receptor alpha ( RARA ) t (15;17) Pathophysiology. PML::RARA fusions are most commonly the result of a balanced translocation between chromosome …

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testing.com

https://www.testing.com/tests/pml-rara/

WEBNov 6, 2020 · PML-RARA is a fusion gene sequence that is associated with acute promyelocytic leukemia (APL), a type of acute myeloid leukemia (AML). This test detects …

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wikipedia.org

https://en.wikipedia.org/wiki/Acute_promyelocytic_leukemia

OverviewPathogenesisSigns and symptomsDiagnosisTreatmentPrognosisEpidemiologyExternal linksAcute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). The RAR receptor is dependent on retinoic acid for regulation of transcription. Usual onset: ~40 years old Frequency: Develops in about 600 to 800 people per year (United States)

Usual onset: ~40 years old

Frequency: Develops in about 600 to 800 people per year (United States)

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nih.gov

https://pubmed.ncbi.nlm.nih.gov/31635329/

WEBOct 18, 2019 · Promyelocytic leukemia-retinoic acid receptor α (PML-RARa) sets the cellular landscape of acute promyelocytic leukemia (APL) by repressing the transcription …

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nature.com

https://www.nature.com/articles/s41408-021-00514-3

WEBJun 30, 2021 · The PML–RARA fusion oncoprotein induces leukemia by blocking normal myeloid differentiation. Before using anthracyclines in APL therapy in 1973, no effective …

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nih.gov

https://pubmed.ncbi.nlm.nih.gov/24720386/

WEBThe t (15;17) (q24;q21), generating a PML-RARA fusion gene, is the hallmark of acute promyelocytic leukemia (APL). At present, eight other genes fusing with RARA have …

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ashpublications.org

https://ashpublications.org/blood/article/133/15/1630/273295/Management-of-acute-promyelocytic-leukemia-updated

WEBApr 11, 2019 · 1.3. Diagnosis should be confirmed by molecular detection of PML-RARA fusion (or rare molecular variants) IIa–B Unchanged 1.4. In addition to FISH, RT-PCR, …

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826966/

WEBOct 18, 2019 · Promyelocytic leukemia-retinoic acid receptor α (PML-RARa) sets the cellular landscape of acute promyelocytic leukemia (APL) by repressing the transcription …

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