Keyword Analysis & Research: nrf2
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NRF2, a Transcription Factor for Stress Response and Beyond
https://pubmed.ncbi.nlm.nih.gov/32640524/
WebJul 6, 2020 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carc ….
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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700122/
WebNov 23, 2020 · Recent studies showed a connection between the Nrf2/antioxidant response element (ARE) system and the expression of inflammatory mediators, NF-κB pathway and macrophage metabolism. This suggests a new strategy for designing chemical agents as modulators of Nrf2 dependent pathways to target the immune response.
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NFE2L2 - Wikipedia
https://en.wikipedia.org/wiki/NFE2L2
WebNRF2 is a basic leucine zipper transcription factor with a Cap “n” Collar (CNC) structure. NRF2 possesses seven highly conserved domains called NRF2-ECH homology (Neh) domains. The Neh1 domain is a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins (MAFF, MAFG, MAFK).
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Nrf2, the Master Regulator of Anti-Oxidative Responses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751370/
WebDec 20, 2017 · 1. Structure and Regulation of Nrf2. The CNC (cap-n-collar) subfamily of the basic region-leucine zipper-type transcription factor Nrf2 is encoded by the nuclear factor, erythroid-derived 2-like 2 ( NFE2L2) gene [ 1 ]. As shown in Figure 1 A, Nrf2 contains six Neh (Nrf2-ECH homology) domains.
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NRF2 has a splicing regulatory function involving the survival
https://www.nature.com/articles/s41388-023-02799-z
WebAug 12, 2023 · 1 Altmetric. Metrics. Abstract. The nuclear factor erythroid 2-like 2 (NFE2L2; NRF2) signaling pathway is frequently deregulated in human cancers. The critical functions of NRF2, other than its...
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Transcription Factor Nrf2 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/transcription-factor-nrf2
WebThe transcription factor Nrf2 (NF-E2-related factor 2) plays a central role in the induction of cytoprotective genes in response to oxidative stress.
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Nrf2, a master regulator of detoxification and also antioxidant, anti
https://pubmed.ncbi.nlm.nih.gov/25672622/
WebFeb 25, 2015 · Nrf2 produces cytoprotection by detoxification mechanisms leading to increased detoxification and excretion of both organic xenobiotics and toxic metals; its action via over two dozen genes increases highly coordinated antioxidant activities; it produces major anti-inflammatory changes; it stimulates mitochondrial biogenesis and otherwise …
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Nrf2 signaling pathway: Pivotal roles in inflammation
https://www.sciencedirect.com/science/article/pii/S0925443916302861
WebFeb 1, 2017 · Nrf2 involves in inflammatory diseases. •. Crosstalk between Nrf2 and NF-ĸB pathways. •. Nrf2 regulates NLRP3 inflammasome activity. •. Nrf2 pathway could be therapeutically exploited. Abstract. Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis.
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NRF2, a Transcription Factor for Stress Response and Beyond
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369905/
WebJul 6, 2020 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges.
DA: 16 PA: 90 MOZ Rank: 59
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Activators and Inhibitors of NRF2: A Review of Their Potential for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664516/
WebJul 14, 2019 · A plethora of NRF2 activators, mostly of electrophilic nature, have been identified and a few are under clinical development. The pleiotropic effects of NRF2 on cell physiology together with potential off-target effects exerted by some NRF2 activators explain why drug development is moving slowly.
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