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MPAL leukemia: Symptoms, diagnosis, and treatments - Medical News Today
https://www.medicalnewstoday.com/articles/mpal-leukemia
Mar 15, 2022 · MPAL is a rare form of blood cancer that presents with clinical features of AML and ALL. As with other acute leukemias, the exact cause is unknown, but many cases are associated with genetic ...
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Mixed phenotype acute leukemia - UpToDate
https://www.uptodate.com/contents/mixed-phenotype-acute-leukemia
Aug 30, 2021 · INTRODUCTION. Mixed phenotype acute leukemia (MPAL) refers to acute leukemia that displays an ambiguous pattern of antigen expression (ie, reflecting more than one hematopoietic lineage), to a degree that it cannot be unequivocally assigned to one lineage. MPAL, as defined by the World Health Organization (WHO), includes categories that were ...
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How I treat mixed-phenotype acute leukemia | Blood | American …
https://ashpublications.org/blood/article/125/16/2477/33762/How-I-treat-mixed-phenotype-acute-leukemia
Apr 16, 2015 · The frequency of translocations involving 11q23 (usually MLL-AF4 or MLL-ENL fusions) decreases with age and is quite uncommon in adults with MPAL. 30 One could argue that leukemia with CK or other myelodysplastic-specific cytogenetic abnormalities should be classified as AML with myelodysplasia-related changes rather than MPAL.
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What is Mixed Phenotype Acute Leukemia (MPAL)? - Healthline
https://www.healthline.com/health/leukemia/mpal-leukemia
Mar 14, 2023 · MPAL is a type of leukemia that has markers from both lymphoid and myeloid lineages. Its symptoms are similar to those of other acute leukemias such as ALL and AML. MPAL can be difficult to ...
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Mixed-Phenotype Acute Leukemia: Clinical Diagnosis and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405901/
Aug 15, 2022 · Abstract. Mixed-phenotype acute leukemia (MPAL) comprises a heterogenous group of leukemias that are genetically, immunophenotypically, and clinically, diverse. Given the rarity of the disease, the diagnosis and treatment of MPAL is extremely challenging. Recent collaborative efforts have made significant progress in understanding the complex ...
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Mixed Phenotype Acute Leukemia: Current Approaches to ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/33544265/
Feb 5, 2021 · Purpose of review: Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia with features of both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The review examines current definitions and controversies in classification of MPAL, new insights into genomic drivers and pathogenesis, recent evidence to ...
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Mixed-phenotype acute leukemia (MPAL) and beyond - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234227/
Dec 23, 2016 · Mixed-phenotype acute leukemia (MPAL) is a rare but difficult to treat hematologic malignancy with immunophenotypic co-expression of at least two cell lineages, or with only rare cases involving all three lineages, e.g. myeloid with B- or T-lymphoid or all three of myeloid, B- and T-lymphoid altogether.
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Mixed Phenotype Acute Leukemia: Current Approaches to
https://link.springer.com/article/10.1007/s11912-020-01010-w
Feb 5, 2021 · Genetic Basis of Mixed Phenotype Acute Leukemia. In children, 15% of MPAL harbors KMT2A r, while MPAL with BCR-ABL translocation is uncommon. Children with KMT2A r MPAL are younger, have B/myeloid immunophenotype, and have fewer cooperating mutations, similar to what is observed in KMT2A r ALL.
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Mixed-phenotype acute leukemia - Wikipedia
https://en.wikipedia.org/wiki/Mixed-phenotype_acute_leukemia
Mixed-phenotype acute leukemia (MPAL) is a group of blood cancers which have combined features of myeloid and lymphoid cancers. It is a rare disease, constituting about 2–5% of all leukemia cases. It mostly involve myeloid with either of T lymphocyte or B lymphocyte progenitors, but in rare cases all the three cell lineages.
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Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469808/
Sep 16, 2021 · Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of ...
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