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CYP3A4 - Wikipedia
https://en.wikipedia.org/wiki/CYP3A4
WEBCytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.
DA: 76 PA: 15 MOZ Rank: 11
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Cytochrome P450 3A inhibitors and inducers - UpToDate
https://www.uptodate.com/contents/image?imageKey=CARD/76992
WEBRefer to UpToDate topics on specific agents and indications for further details. CYP: cytochrome P450. * Mifepristone is a significant inhibitor of CYP3A4 when used chronically (eg, for hyperglycemia in patients with Cushing syndrome), not in single-dose use.
DA: 58 PA: 94 MOZ Rank: 20
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CYP3A4 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/cyp3a4
WEBThe human cytochrome P450 3A4 (CYP3A4) is the largest member of the CYP3A subfamily and accounts for 30–60% of the total for CYP450 adult liver. The CYP3A4 gene is localized on chromosome 7q21 and up to now, 41 CYP3A4 alleles have been identified.
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UNDERSTANDING THE MECHANISM OF CYTOCHROME …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787833/
WEBMar 3, 2013 · Among 57 human P450s, the 3A4 isoform (CYP3A4) is the most abundant and the most important because it metabolizes the majority of the administered drugs. A remarkable feature of CYP3A4 is its extreme promiscuity in substrate specificity and cooperative substrate binding, which often leads to undesirable drug-drug interactions …
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The Role of CYP3A in Health and Disease - PMC - National …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687714/
WEBOct 24, 2022 · CYP3A4 mRNA expression shows 10-fold variation and increases with age after conception [30,31]. CYP3A5 is the most abundant and best studied among minor isoforms of CYP3A [6,8]. Unlike CYP3A4, functional CYP3A5 is expressed in approximately 70% of Africans and Afro-Americans and only in 20% of Eurasians [8,12,13].
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Inhibition and induction of CYP enzymes in humans: an update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603454/
WEBOct 27, 2020 · As CYP3A4 is involved in the metabolism of approximately 50% of all marketed medications (Zhou 2008), its induction is of special importance. There are also numerous pharmaceutical CYP3A4 inducers leading to increased risk of drug–drug interactions (Table 12). CAR, GR, and PXR are known to mediate the induction.
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The genetic landscape of major drug metabolizing cytochrome
https://www.nature.com/articles/s41397-022-00288-2
WEBSep 6, 2022 · Among the major drug metabolizing CYPs, CYP3A4 is the only enzyme with an important endogenous substrate and, as a consequence, CYP3A4 is the most conserved among the studied CYPs (Table 5 and...
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CYP3A4 - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cyp3a4
WEBThe CYP3A4 enzyme plays a role in the first oxidation step of clopidogrel to 2-oxo-clopidogrel. Drug interactions by substrates and inhibitors of the CYP3A4 enzyme can alter the response to clopidogrel. The CYP3A4 enzyme itself can show considerable interindividual variation, which can impact on clopidogrel metabolism and effect [40].
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Frontiers | CYP3A4∗22 Genotyping in Clinical Practice: Ready for
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.711943/full
WEBJul 7, 2021 · This information may help in deciding if, and for which drugs, CYP3A4∗22 genotype-based dosing could be helpful in improving drug therapy. CYP3A4∗22 was shown to significantly influence the pharmacokinetics of several drugs, with currently being most thoroughly investigated tacrolimus, cyclosporine, and statins.
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CYP3A - Wikipedia
https://en.wikipedia.org/wiki/CYP3A
WEBCYP3A4, CYP3A5, CYP3A7, and; CYP3A43. The region also contains four pseudogenes: CYP3A51P, CYP3A52P, CYP3A54P, and; CYP3A137P. as well as several extra exons which may or may not be included in transcripts produced from this region.
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