Keyword Analysis & Research: ctla
Keyword Research: People who searched ctla also searched
Search Results related to ctla on Search Engine
-
Cytotoxic T-lymphocyte associated protein 4 - Wikipedia
https://en.wikipedia.org/wiki/Cytotoxic_T-lymphocyte_associated_protein_4
WEBCytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 ( cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.
DA: 57 PA: 88 MOZ Rank: 45
-
Current understanding of CTLA-4: from mechanism to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367421/
WEBJul 11, 2023 · In this review, we first describe the structure, expression, and how the signaling pathways of CTLA-4 participate in reducing effector T-cell activity and enhancing the immunomodulatory ability of regulatory T (Treg) cells to reduce immune response, maintain immune homeostasis, and maintain autoimmune silence.
DA: 86 PA: 10 MOZ Rank: 25
-
CTLA-4: a moving target in immunotherapy - PMC - National …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317697/
WEBJan 1, 2018 · CTLA-4 function and the impact of immune checkpoint blockade (A) In health, regulatory T cells express CTLA-4, which binds CD80 and CD86 expressed on antigen presenting cells (APCs). CTLA-4 binds to CD80 and CD86 with higher affinity and avidity than does CD28, preventing Tcon stimulation through CD80/CD86 interaction with CD28.
DA: 6 PA: 57 MOZ Rank: 57
-
CTLA-4: a moving target in immunotherapy | Blood | American …
https://ashpublications.org/blood/article/131/1/58/107717/CTLA-4-a-moving-target-in-immunotherapy
WEBJan 4, 2018 · CTLA-4 function and the impact of immune checkpoint blockade. (A) In health, Tregs express CTLA-4, which binds CD80 and CD86 expressed on APCs. CTLA-4 binds to CD80 and CD86 with higher affinity and avidity than does CD28, preventing conventional T cell (Tcon) stimulation through CD80/CD86 interaction with CD28.
DA: 28 PA: 17 MOZ Rank: 26
-
CTLA-4 blockade drives loss of T - Nature
https://www.nature.com/articles/s41586-021-03326-4
WEBFeb 15, 2021 · Overall, these results suggest that CTLA-4 blockade can be best exploited to treat glycolysis-low tumours or in combination with inhibitors of tumour glycolysis 33, 34, 35, 36 that can increase...
DA: 40 PA: 99 MOZ Rank: 55
-
CTLA-4: Checkpoints beyond the membrane: Molecular Therapy
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(24)00002-9
WEBJan 17, 2024 · The discovery that the checkpoint receptors CTLA-4 and PD-1 regulate anti-tumor T cell immunity has revolutionized the field of cancer therapy since ipilimumab, a monoclonal antibody (mAb) specific for CTLA-4, was first shown to prolong survival in patients with difficult-to-treat metastatic melanoma over 10 years ago.
DA: 85 PA: 13 MOZ Rank: 27
-
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005092/
WEBMar 22, 2021 · This review will describe the mechanisms of CTLA-4 immune checkpoint inhibition, the role of T reg cells in tumorigenesis, and how anti-CTLA-4 antibodies can provoke an alteration in the expression of CTLA-4 on T reg cells while exerting anti-cancer therapeutic activity.
DA: 17 PA: 57 MOZ Rank: 45
-
Two CTLA-4 ligands, separate pHates | Nature Immunology
https://www.nature.com/articles/s41590-022-01296-x
WEBAug 23, 2022 · INHIBITORY MOLECULE REGULATION. Two CTLA-4 ligands, separate pHates. Preston A. Humphries & Wan-Lin Lo. Nature Immunology 23 , 1297–1299 ( 2022) Cite this article. 2671 Accesses. 3 Citations. 6...
DA: 69 PA: 17 MOZ Rank: 15
-
CTLA-4: new insights into its biological function and use in tumor
https://www.nature.com/articles/ni0702-611
WEBJul 1, 2002 · We summarize here recent findings that suggest a previously unrecognized role for CTLA-4 in the regulation of T cell responses.
DA: 38 PA: 30 MOZ Rank: 42
-
CTLA4 Deficiency - National Institute of Allergy and Infectious
https://www.niaid.nih.gov/diseases-conditions/ctla4-deficiency
WEBCTLA4 Deficiency. CTLA4 deficiency is a rare disorder that severely impairs the normal regulation of the immune system, resulting in conditions such as intestinal disease, respiratory infections, autoimmune problems, and enlarged lymph nodes, liver, and spleen.
DA: 66 PA: 10 MOZ Rank: 58
