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Carnitine palmitoyltransferase I - Wikipedia
https://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_I
WebThree isoforms of CPT1 are currently known: CPT1A, CPT1B, and CPT1C. CPT1 is associated with the outer mitochondrial membrane. This enzyme can be inhibited by malonyl CoA, the first committed intermediate produced during fatty acid synthesis.
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Carnitine Palmitoyltransferase 1A Deficiency - GeneReviews®
https://www.ncbi.nlm.nih.gov/books/NBK1527/
WebJul 27, 2005 · Carnitine palmitoyltransferase 1A (CPT1A) deficiency is a disorder of long-chain fatty acid oxidation. Clinical manifestations usually occur in an individual with a concurrent febrile or gastrointestinal illness when energy demands are increased; onset of symptoms is usually rapid.
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CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/31900483/
WebFeb 1, 2020 · The CPT1 family of proteins contains 3 isoforms: CPT1A, CPT1B, and CPT1C. This review focuses on CPT1A, the liver isoform that catalyzes the rate-limiting step of converting acyl-coenzyme As into acyl-carnitines, which can then cross membranes to get into the mitochondria.
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CPT1A gene: MedlinePlus Genetics
https://medlineplus.gov/genetics/gene/cpt1a/
WebThe CPT1A gene provides instructions for making an enzyme called carnitine palmitoyltransferase 1A, which is found in the liver. This enzyme is essential for fatty acid oxidation, a multistep process that breaks down (metabolizes) fats and converts them into energy. Fatty acid oxidation takes place within mitochondria, which are the energy ...
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CPT1A Gene - GeneCards | CPT1A Protein | CPT1A Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CPT1A
WebApr 2, 2024 · Complete information for CPT1A gene (Protein Coding), Carnitine Palmitoyltransferase 1A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium.
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CPT1A-mediated fatty acid oxidation promotes cell ... - Nature
https://www.nature.com/articles/s41419-022-04730-y
WebApr 11, 2022 · 29 Citations. 1 Altmetric. Metrics. Abstract. As the first rate-limiting enzyme in fatty acid oxidation (FAO), CPT1 plays a significant role in metabolic adaptation in cancer pathogenesis. FAO...
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Upregulation of CPT1A is essential for the tumor-promoting
https://www.nature.com/articles/s41419-020-02936-6
WebSep 10, 2020 · Here we demonstrate that carnitine palmitoyltransferase I (CPT1A), a key enzyme controlling fatty acid oxidation (FAO), was upregulated in colon cancer cells upon exposure to adipocytes or...
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CPT1A plays a key role in the development and treatment of
https://www.nature.com/articles/s41598-019-49868-6
WebSep 16, 2019 · Human mutations in carnitine palmitoyl transferase 1A ( CPT1A) are correlated with a remarkably low prevalence of multiple sclerosis (MS) in Inuits (P479L) and Hutterites (G710E). To elucidate...
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Mitochondrial CPT1A: Insights into structure, function, and
https://pubmed.ncbi.nlm.nih.gov/37033619/
WebMar 23, 2023 · Abstract. Carnitine Palmitoyl-Transferase1A (CPT1A) is the rate-limiting enzyme in the fatty acid β-oxidation, and its deficiency or abnormal regulation can result in diseases like metabolic disorders and various cancers. Therefore, CPT1A is a desirable drug target for clinical therapy.
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CPT1A carnitine palmitoyltransferase 1A [ (human)]
https://www.ncbi.nlm.nih.gov/gene/1374
WebApr 7, 2024 · CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis. Augmented CPT1A Expression Is Associated with Proliferation and Colony Formation during Barrett's Tumorigenesis. The role of CPT1A as a biomarker of breast cancer progression: a bioinformatic approach.
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