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Assay Development in Drug Discovery - A Comprehensive Guide …
https://lifesciences.danaher.com/us/en/library/assay-development.html
WEBThe assay should be efficient for high-throughput screening, biologically relevant, and economical. In this article, we review the types of assays developed during drug development, their process, and what challenges drug manufacturers face while designing an efficient assay to assess drugs.
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Assay Development: An Overview | Technology Networks
https://www.technologynetworks.com/drug-discovery/articles/assay-development-329953
WEBJan 31, 2020 · The purpose of assay development and screening in drug discovery. Assays are investigative procedures that qualitatively assess a compound or examine a compound’s effects on identified molecular, cellular, or biochemical targets. The first steps in drug development are the identification and validation of potential drug targets involved …
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Assay Development: 5 Considerations and 8 Fundamentals
https://www.labome.com/method/Assay-Development-5-Considerations-and-8-Fundamentals.html
WEBOct 21, 2022 · The key aspects of assay development discussed in this article are of general applicability. They are valid regardless of the type of assay to be developed (e.g., antibody-based assays such as ELISA and electrochemiluminescence, determination of total protein/protein concentration, enzyme activity assays, cell-based assays or …
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Assay Guidance Manual - NCBI Bookshelf - National Center for
https://www.ncbi.nlm.nih.gov/books/NBK53196/
WEBTopics addressed in this manual include: Descriptions of assay formats that are compatible with HTS and determination of SAR. Selection and development of optimal assay reagents. Optimizations and troubleshooting for assay protocols with respect to sensitivity, dynamic range, signal intensity and stability.
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Assay Guidance Manual - National Center for Biotechnology …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132369/
WEBJul 24, 2018 · The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening …
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Assay Development | ATCC
https://www.atcc.org/the-science/assay-development
WEBAssay Development. Keep your assays on target. Assay accuracy depends on credible materials. From unraveling the mysteries of the microbiome to identifying the underlying genetics behind a disease, assays offer scientists …
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Preface - Assay Guidance Manual - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK92019/
WEBMay 1, 2012 · There are three fundamental areas in assay development and validation: (a) pre-study (pre-screen) validation, (b) in-study (in-screen) validation, and (c) cross-validation or assay transfer validation. These stages encompass the systematic scientific steps within the assay development and validation cycle.
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Assay development: an increasingly creative endeavour - Nature
https://www.nature.com/articles/nrd1916
WEBAssay development in drug discovery is very much an exercise in quantitative biology — the need to make sense of large datasets and to understand complex data relationships is more important ...
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Assay development | Nature Reviews Drug Discovery
https://www.nature.com/articles/nrd2383
WEBAbstract. High-throughput screening is a core technology in drug discovery. This month, we feature two people who have been in the field since its inception: one developing assays at a ...
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Assay Guidance Manual for Drug Discovery: Robust or Go …
https://journals.sagepub.com/doi/pdf/10.1177/24725552211054044
WEBThe articles span a wide range of topics within the scope of the AGM workshop series and can generally be grouped into the following topic areas: (1) best practices in assay development, data analy-sis, and implementation for high-throughput screening (HTS) and lead discovery; (2) assay development and validation; and (3) the utility of speciali...
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