Keyword Analysis & Research: arrestin
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Arrestin - Wikipedia
https://en.wikipedia.org/wiki/Arrestin
WEBArrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors.
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β -Arrestins: Structure, Function, Physiology, and ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/37028945/
WEBAbstract. The two β -arrestins, β -arrestin-1 and -2 (systematic names: arrestin-2 and -3, respectively), are multifunctional intracellular proteins that regulate the activity of a very large number of cellular signaling pathways and physiologic functions.
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GPCR signaling via β-arrestin-dependent mechanisms - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591062/
WEBβ-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic adaptor proteins that were originally discovered for their inhibitory role in G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins.
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Arrestin - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/arrestin
WEBArrestins are adaptor proteins that function to regulate G protein-coupled receptor (GPCR) signaling and trafficking. There are four mammalian members of the arrestin family, two visual and two nonvisual.
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GPCR Signaling Regulation: The Role of GRKs and Arrestins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389790/
WEBFeb 19, 2019 · We use systematic names of arrestin proteins, where the number after the dash indicates the order of cloning: arrestin-1 (historic names S-antigen, 48 kDa protein, visual or rod arrestin), arrestin-2 (β-arrestin or β-arrestin1), arrestin-3 (β-arrestin2 or hTHY-ARRX), and arrestin-4 (cone or X-arrestin).
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The multifaceted functions of β-arrestins and their therapeutic
https://www.nature.com/articles/s12276-023-01144-4
WEBJan 11, 2024 · Arrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR) desensitization, signaling, and internalization. The arrestin family consists of four subtypes: visual...
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Receptor-Arrestin Interactions: The GPCR Perspective - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913897/
WEBFeb 4, 2021 · Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins, facilitating receptor internalization, and initiating distinct arrestin-mediated signaling.
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A complex structure of arrestin-2 bound to a G protein-coupled …
https://www.nature.com/articles/s41422-019-0256-2
WEBNov 27, 2019 · 128 Citations. 12 Altmetric. Metrics. Abstract. Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs), which include arrestins 1 to 4. While arrestins 1 and...
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Structural studies of phosphorylation-dependent interactions
https://www.nature.com/articles/s41467-021-22731-x
WEBPublished: 22 April 2021. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Qing-Tao He, Peng Xiao, Shen-Ming Huang, Ying-Li Jia, Zhong-Liang...
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Arrestins: ubiquitous regulators of cellular signaling pathways
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2006-7-9-236
WEBOct 2, 2006 · 217 Citations. 3 Altmetric. Metrics. Summary. In vertebrates, the arrestins are a family of four proteins that regulate the signaling and trafficking of hundreds of different G-protein-coupled receptors (GPCRs). Arrestin homologs are also found in insects, protochordates and nematodes.
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