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ACSL1 - Wikipedia
https://en.wikipedia.org/wiki/ACSL1
WEBACSL1 is known to be involved in fatty-acid metabolism critical for heart function and nonspecific mental retardation. Since the ACSL4 gene is highly expressed in brain, where it encodes a brain specific isoform, an ASCL1 mutation may be an efficient diagnostic tool in mentally retarded males.
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ACSL1 Gene - GeneCards | ACSL1 Protein | ACSL1 Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ACSL1
WEBApr 2, 2024 · ACSL1 (Acyl-CoA Synthetase Long Chain Family Member 1) is a Protein Coding gene. Diseases associated with ACSL1 include Platelet Glycoprotein Iv Deficiency and Occupational Dermatitis. Among its related pathways are Fatty acid metabolism and arachidonate biosynthesis III (metazoa).
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ACSL family: The regulatory mechanisms and therapeutic
https://www.sciencedirect.com/science/article/pii/S0014299921005501
WEBOct 15, 2021 · Long-chain acyl-coenzyme A synthases (ACSLs) are responsible for activating long-chain FAs and are frequently deregulated in cancers. Among the five mammalian ACSL family members, ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression.
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ACSL1-induced ferroptosis and platinum resistance in ovarian
https://www.nature.com/articles/s41420-023-01385-2
WEBMar 8, 2023 · Mechanistically, ACSL1 increased the N-myristoylation of ferroptosis suppressor 1 (FSP1), resulting in the inhibition of its degradation and translocation to the cell membrane. The increase in...
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ACSL1 acyl-CoA synthetase long chain family member 1 [ (human)]
https://www.ncbi.nlm.nih.gov/gene/2180
WEBApr 3, 2024 · ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease. Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
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ACSL family: The regulatory mechanisms and therapeutic
https://www.sciencedirect.com/science/article/abs/pii/S0014299921005501
WEBOct 15, 2021 · Among the five mammalian ACSL family members, ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression. ACSL3 is an androgen-responsive gene.
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ACSL1 is a key regulator of inflammatory and macrophage
https://www.sciencedirect.com/science/article/pii/S2589004223012221
WEBJul 21, 2023 · ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding - ScienceDirect. iScience. Volume 26, Issue 7, 21 July 2023, 107145. Article. ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat …
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ACSL family: The regulatory mechanisms and therapeutic
https://pubmed.ncbi.nlm.nih.gov/34332918/
WEBOct 15, 2021 · Among the five mammalian ACSL family members, ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression. ACSL3 is an androgen-responsive gene.
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ACSL1 affects Triglyceride Levels through the PPARγ Pathway
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085263/
WEBFeb 24, 2020 · In clinical cohort studies, high expression of long-chain acyl-coenzyme A synthetases 1 (ACSL1 gene) in peripheral white blood cells of patients with acute myocardial infarction (AMI) has been utilized as molecular markers …
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An Essential Role of the N-Terminal Region of ACSL1 in Linking …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490201/
WEBSep 9, 2021 · Several reports have shown that ACSL1, among the ACSLs, is located in mitochondria and mainly leads fatty acids to the β-oxidation pathway in various cell types. In this study, we investigated how ACSL1 was localized in mitochondria and whether ACSL1 overexpression affected fatty acid oxidation (FAO) rates in C2C12 myotubes.
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