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Adeno-associated virus - Wikipedia
https://en.wikipedia.org/wiki/Adeno-associated_virus
WebIn March 2023, a series of Nature papers detected high titres of adeno-associated virus 2 (AAV2), alongside adenovirus and herpesvirus, in samples from a wave of childhood hepatitis. One paper suggested that AAV2 co-infection may contribute to more serious liver disease than infection with only adeno- or herpesviruses and that the causal link ...
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Addgene: Adeno-associated virus (AAV) Guide
https://www.addgene.org/guides/aav/
WebEleven serotypes of AAV have thus far been identified, with the best characterized and most commonly used being AAV2. These serotypes differ in their tropism, or the types of cells they infect, making AAV a very useful system for …
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Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548848/
WebJul 1, 2017 · AAV2 was one of the first AAV serotypes identified and characterized, including the sequence of its genome. As a result of the detailed understanding of AAV2 biology from this early work, most rAAV vectors generated today …
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Adeno-Associated Virus (AAV) Gene Delivery: Dissecting …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310307/
WebJul 10, 2021 · For example, AAV2 was used to characterize the first AAV glycan attachment factors and deduce the first high-resolution AAV structure, and AAV2 served as the basis for the first genome-wide screen to identify protein entry receptors [22,24,36,37]. More recently, AAV2 was the model serotype for systematic genotype-phenotype investigation .
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Introduction to Adeno-Associated Viruses (AAV) - Vector Biolabs
https://www.vectorbiolabs.com/intro-to-aav/
WebAAV2 is probably the most widely used AAV serotype for in vitro and in vivo gene delivery. However, many other serotypes of AAV have been isolated, and every year there are new serotypes being discovered. Among them, AAV1, AAV2, AAV5, as well as AAV7, 8 and 9 etc, have been used for gene delivery studies.
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Adeno-associated virus vector as a platform for gene therapy
https://www.nature.com/articles/s41573-019-0012-9
WebFeb 1, 2019 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids,...
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Adeno-associated virus 2 bound to its cellular receptor AAVR
https://www.nature.com/articles/s41564-018-0356-7
WebFeb 11, 2019 · The structure of adeno-associated virus (AAV) type 2 in complex with its receptor, AAVR, provides new insights on the molecular mechanism of AAV entry into host cells and will serve to optimize ...
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Production of adeno-associated virus vectors for
https://www.nature.com/articles/s41598-019-49624-w
WebSep 19, 2019 · Engineering adeno-associated virus vectors for gene therapy. Article 10 February 2020. Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression. Article Open...
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Adeno-associated virus 2 bound to its cellular receptor AAVR
https://pubmed.ncbi.nlm.nih.gov/30742069/
WebPMID: 30742069. DOI: 10.1038/s41564-018-0356-7. Abstract. Adeno-associated virus (AAV) is a leading vector for virus-based gene therapy. The receptor for AAV (AAVR; also named KIAA0319L) was recently identified, and the precise characterization of AAV-AAVR recognition is in immediate demand.
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Adeno-associated virus type 2 (AAV2) uncoating is a stepwise
https://pubmed.ncbi.nlm.nih.gov/35816507/
WebJul 11, 2022 · Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolus. PLoS Pathog. 2022 Jul 11;18 (7):e1010187. doi: 10.1371/journal.ppat.1010187. eCollection 2022 Jul. Authors.
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